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- aggregation classification "A1".
- aggregation creator B33263.
- aggregation creator B33264.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "1998".
- aggregation format "application/pdf".
- aggregation hasFormat 179961.bibtex.
- aggregation hasFormat 179961.csv.
- aggregation hasFormat 179961.dc.
- aggregation hasFormat 179961.didl.
- aggregation hasFormat 179961.doc.
- aggregation hasFormat 179961.json.
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- aggregation hasFormat 179961.mods.
- aggregation hasFormat 179961.rdf.
- aggregation hasFormat 179961.ris.
- aggregation hasFormat 179961.txt.
- aggregation hasFormat 179961.xls.
- aggregation hasFormat 179961.yaml.
- aggregation isPartOf urn:issn:0195-668X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients".
- aggregation abstract "Aims The purpose of this study was to examine, in chronically treated heart failure patients vs control subjects, the influence of neurohumoral activation and aldosterone escape on arterial elastic behaviour, assessed by noninvasive mathematical lumped-parameter modelling of the compliance of the arterial system. Methods and Results Radial arterial pulse waves were recorded non-invasively for 30 s with an arterial tonometer sensor array in 13 chronic heart failure patients (mean age, 59 +/- 2.5 years) in New York Heart Association class II. The patients had been taking digoxin, furosemide, captopril and aspirin for more than 3 months. Thirteen healthy subjects (mean age, 50 +/- 4.0 years) acted as controls. Compliance of the proximal (aorta and major branches, C1) and distal parts (C2) of the circulation were derived from a third order four-element modified Windkessel model which can reproduce arterial pressure waveforms, including both exponential and oscillatory sections. Active renin, angiotensin II and aldosterone levels were determined on venous blood samples in the supine position and after 30 min active standing. There was decreased proximal (C1, 1.51 +/- 0.11 ml . mmHg(-1), P<0.01) and distal (C2, 0050+/-0.011 ml . mmHg(-1)) arterial compliance in the chronic heart failure patients vs controls (C1, 1.71 +/- 0.16 ml. mmHg(-1); C2, 0.054 +/- 0.006 ml . mmHg(-1)). The chronic heart failure patients were characterized by an aldosterone escape phenomenon which was inversely correlated with the proximal arterial compliance in both supine (r= -0.795, P=0.002) and standing (r= -0.628, P=0.029) positions. Conclusions In chronically treated heart failure patients with full angiotensin-converting enzyme-inhibition and diuretics, there is decreased compliance of the aorta and its major branches, which is inversely correlated with the aldosterone escape phenomenon.".
- aggregation authorList BK83903.
- aggregation endPage "1376".
- aggregation issue "9".
- aggregation startPage "1371".
- aggregation volume "19".
- aggregation aggregates 2107415.
- aggregation isDescribedBy 179961.
- aggregation similarTo euhj.1998.1099.
- aggregation similarTo LU-179961.