Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1870245#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B382626.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1870245.bibtex.
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- aggregation isPartOf urn:issn:0090-6964.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Technology and Engineering".
- aggregation title "An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice".
- aggregation abstract "Locally disturbed flow has been suggested to play a (modulating) role in abdominal aortic aneurysm (AAA) formation, but no longitudinal studies have been performed yet due to (a.o.) a lack of human data prior to AAA formation. In this study we made use of recent advances in small animal imaging technology in order to set up entirely mouse-specific computational fluid dynamics (CFD) simulations of the abdominal aorta in an established ApoE 2/2 mouse model of AAA formation, combining (i) in vivo contrast-enhanced micro-CT scans (geometrical model) and (ii) in vivo high-frequency ultrasound scans (boundary conditions). Resulting areas of disturbed flow at baseline were compared to areas of AAA at end-stage. Qualitative results showed that AAA dimension is maximal in areas that are situated proximal to those areas that experience most disturbed flow in three out of four S developing an AAA. Although further quantitative analysis did not reveal any obvious relationship between areas that experience most disturbed flow and the end-stage AAA dimensions, we cannot exclude that hemodynamics play a role in the initial phases of AAA formation. Due to its mouse-specific and in vivo nature, the presented methodology can be used in future research to link detailed and animal-specific (baseline) hemodynamics to (end-stage) arterial disease in longitudinal studies in mice.".
- aggregation authorList BK691411.
- aggregation endPage "2444".
- aggregation issue "9".
- aggregation startPage "2430".
- aggregation volume "39".
- aggregation aggregates 3147086.
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- aggregation similarTo s10439-011-0330-5.
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