Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1925272#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B258591.
- aggregation creator B258592.
- aggregation creator B258593.
- aggregation creator B258594.
- aggregation creator B258595.
- aggregation creator B258596.
- aggregation creator B258597.
- aggregation creator B258598.
- aggregation creator B258599.
- aggregation creator person.
- aggregation date "1991".
- aggregation hasFormat 1925272.bibtex.
- aggregation hasFormat 1925272.csv.
- aggregation hasFormat 1925272.dc.
- aggregation hasFormat 1925272.didl.
- aggregation hasFormat 1925272.doc.
- aggregation hasFormat 1925272.json.
- aggregation hasFormat 1925272.mets.
- aggregation hasFormat 1925272.mods.
- aggregation hasFormat 1925272.rdf.
- aggregation hasFormat 1925272.ris.
- aggregation hasFormat 1925272.txt.
- aggregation hasFormat 1925272.xls.
- aggregation hasFormat 1925272.yaml.
- aggregation isPartOf urn:issn:0041-1337.
- aggregation language "eng".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Evidence that pentoxifylline reduces anti-CD3 monoclonal antibody-induced cytokine release syndrome".
- aggregation abstract "Pretreatment with pentoxifylline (PTX), a methylxanthine known for its beneficial effects on tissue lesions induced by the injection of endotoxin or recombinant cytokines, was shown to decrease the systemic release of tumor necrosis factor and interleukin 2 occurring after the administration of the anti-CD3 monoclonal antibody 145-2C11 in mice. In parallel, PTX attenuated the hypothermia and the rise in blood urea nitrogen observed in this model. The protective effect of PTX on the toxicity of 145-2C11 was confirmed by the reduction of the mortality among D-galactosamine-sensitized animals. The mitigation by PTX of the release of cytokines did not affect the immunosuppression entailed by 145-2C11 as assessed by the unmodified cytotoxic T lymphocytes (CTL) unresponsiveness against alloantigens measured 48 hr after the injection of the mAb. In vitro experiments on human peripheral blood leukocytes indicated that PTX alone or in synergy with methylprednisolone (m-PDS) also inhibited the release of TNF and IL-2 induced by OKT3. Finally, in a preliminary pilot trial conducted in kidney transplant recipients, we observed that pretreatment with PTX (20 mg/kg i.v.) in addition to m-PDS (2 g i.v.) reduced by half the amount of TNF released in the blood stream after the first injection of OKT3, while no further reduction of the low levels of IL-2 was found.".
- aggregation authorList BK535498.
- aggregation endPage "679".
- aggregation issue "4".
- aggregation startPage "674".
- aggregation volume "52".
- aggregation isDescribedBy 1925272.
- aggregation similarTo 00007890-199110000-00018.
- aggregation similarTo LU-1925272.