Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1925312#aggregation> ?p ?o. }
Showing items 1 to 32 of
32
with 100 items per page.
- aggregation classification "A1".
- aggregation creator person.
- aggregation date "1991".
- aggregation format "application/pdf; charset=binary".
- aggregation hasFormat 1925312.bibtex.
- aggregation hasFormat 1925312.csv.
- aggregation hasFormat 1925312.dc.
- aggregation hasFormat 1925312.didl.
- aggregation hasFormat 1925312.doc.
- aggregation hasFormat 1925312.json.
- aggregation hasFormat 1925312.mets.
- aggregation hasFormat 1925312.mods.
- aggregation hasFormat 1925312.rdf.
- aggregation hasFormat 1925312.ris.
- aggregation hasFormat 1925312.txt.
- aggregation hasFormat 1925312.xls.
- aggregation hasFormat 1925312.yaml.
- aggregation isPartOf urn:issn:0014-5793.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Tumor necrosis factor: characterization at the molecular, cellular and in vivo level".
- aggregation abstract "TNF was originally characterized as an antitumor agent and a factor cytotoxic for many malignant cells. It is now clear that it plays an important role in the defense against viral, bacterial and parasitic infections, - and in (auto-)immune responses. Natural induction of TNF is protective, but its overproduction may be detrimental and even lethal to the host. The structure of TNF and its interaction with the two types of cellular receptor are becoming better understood. TNF elicits a variety of events in different cell types. It subverts the electron transport system or the mitochondria into production of oxygen radicals, which can kill the (malignant) cells when these do not contain or produce protective enzymes. Furthermore, TNF induces a set of genes and at least part of this transcriptional activation is mediated by NF-kappa-B. The prospects of TNF as an antitumor drug can be improved on the one hand by agents such as LI+, which synergizes, and on the other hand by inhibitors of the systemic toxicity which do not interfere with the antitumor efficacy. Also, in tumor-bearing animals which have been rendered tolerant by administration of small doses of TNF, an effective and complete elimination of the tumors can be obtained by the combined action of TNF plus interferon.".
- aggregation authorList BK693839.
- aggregation endPage "212".
- aggregation issue "2".
- aggregation startPage "199".
- aggregation volume "285".
- aggregation aggregates 1927610.
- aggregation isDescribedBy 1925312.
- aggregation similarTo 0014-5793(91)80803-B.
- aggregation similarTo LU-1925312.