Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1925329#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B383809.
- aggregation creator B383810.
- aggregation creator B383811.
- aggregation creator B383812.
- aggregation creator B383813.
- aggregation creator B383814.
- aggregation creator person.
- aggregation date "1991".
- aggregation format "application/pdf; charset=binary".
- aggregation hasFormat 1925329.bibtex.
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- aggregation isPartOf urn:issn:0008-5472.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α".
- aggregation abstract "Multiple cytokines stimulate hepatic lipogenesis in rodents. We have previously shown that lipogenic cytokines can be divided into 2 classes by their mechanism of action and their synergistic interactions. We now report the effects of interleukin 4, a cytokine known to inhibit the synthesis and action of other cytokines. Interleukin 4 by itself did not alter hepatic lipogenesis. However, interleukin 4 inhibited the characteristic stimulation of hepatic lipogenesis that is seen with tumor necrosis factor, interleukin 1, and interleukin 6. These 3 cytokines stimulate hepatic lipogenesis by the same mechanism, increasing hepatic levels of citrate, a key allosteric activator of acetyl CoA carboxylase, the rate-limiting enzyme of fatty acid synthesis. Interleukin 4 blocks the ability of tumornecrosis factor to increase hepatic citrate. In contrast, interleukin 4 does not block the stimulation of hepatic lipogenesis by interferon-alpha, a cytokine that increases hepatic lipogenesis by a mechanism other than increasing hepatic citrate levels. These results demonstrate that interleukin 4 can inhibit the metabolic action of selected cytokines, which provides strong support for our proposal that lipogenic cytokines operate through 2 distinct mechanisms of action and can therefore be divided into 2 separate classes based on their interactions. These results also emphasize the multiple relationships between the immune response and lipid metabolism.".
- aggregation authorList BK693832.
- aggregation endPage "2807".
- aggregation issue "11".
- aggregation startPage "2803".
- aggregation volume "51".
- aggregation aggregates 1927631.
- aggregation isDescribedBy 1925329.
- aggregation similarTo LU-1925329.