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- aggregation classification "A1".
- aggregation creator B258578.
- aggregation creator B258579.
- aggregation creator B258580.
- aggregation creator B258581.
- aggregation creator person.
- aggregation date "1991".
- aggregation format "application/pdf".
- aggregation hasFormat 1925417.bibtex.
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- aggregation isPartOf urn:issn:0002-9440.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro".
- aggregation abstract "Tumor necrosis factor (TNF) is cytotoxic for many tumoral cell lines, whereas normal cells generally are considered resistant to this action. This study shows that this cytokine causes massive death of bovine endothelial cells in primary culture in a concentration- and time-dependent manner. Dying cells exhibit all the ultrastructural changes and the internucleosome cleavage of DNA associated with apoptosis or 'programmed cell death.' This is the first report clearly showing a direct toxicity of TNF on endothelial cells and demonstrating that this results from the induction of the program of apoptotic death. Our observation raises the possibility that hemorrhagic necrosis in vivo, after treatment with TNF, might involve a direct cytocidal action on endothelial cells of the tumor neovasculature.".
- aggregation authorList BK535479.
- aggregation endPage "453".
- aggregation issue "2".
- aggregation startPage "447".
- aggregation volume "138".
- aggregation aggregates 1940245.
- aggregation isDescribedBy 1925417.
- aggregation similarTo LU-1925417.