Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1930990#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B506680.
- aggregation creator B506681.
- aggregation creator B506682.
- aggregation creator B506683.
- aggregation creator B506684.
- aggregation creator B506685.
- aggregation creator B506686.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1930990.bibtex.
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- aggregation hasFormat 1930990.dc.
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- aggregation hasFormat 1930990.doc.
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- aggregation isPartOf urn:issn:1619-7070.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications".
- aggregation abstract "The serotonergic system of the brain is complex, with an extensive innervation pattern covering all brain regions and endowed with at least 15 different receptors (each with their particular distribution patterns), specific reuptake mechanisms and synthetic processes. Many aspects of the functioning of the serotonergic system are still unclear, partially because of the difficulty of measuring physiological processes in the living brain. In this review we give an overview of the conventional methods of measuring serotonin synthesis and methods using positron emission tomography (PET) tracers, more specifically with respect to serotonergic function in affective disorders. Conventional methods are invasive and do not directly measure synthesis rates. Although they may give insight into turnover rates, a more direct measurement may be preferred. PET is a noninvasive technique which can trace metabolic processes, like serotonin synthesis. Tracers developed for this purpose are alpha-[(11)C]methyltryptophan ([(11)C]AMT) and 5-hydroxy-L-[beta-(11)C]tryptophan ([(11)C]5-HTP). Both tracers have advantages and disadvantages. [(11)C]AMT can enter the kynurenine pathway under inflammatory conditions (and thus provide a false signal), but this tracer has been used in many studies leading to novel insights regarding antidepressant action. [(11)C]5-HTP is difficult to produce, but trapping of this compound may better represent serotonin synthesis. AMT and 5-HTP kinetics are differently affected by tryptophan depletion and changes of mood. This may indicate that both tracers are associated with different enzymatic processes. In conclusion, PET with radiolabelled substrates for the serotonergic pathway is the only direct way to detect changes of serotonin synthesis in the living brain.".
- aggregation authorList BK850436.
- aggregation endPage "591".
- aggregation issue "3".
- aggregation startPage "576".
- aggregation volume "38".
- aggregation aggregates 1931898.
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- aggregation similarTo s00259-010-1663-2.
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