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- aggregation classification "A1".
- aggregation creator B506656.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1940901.bibtex.
- aggregation hasFormat 1940901.csv.
- aggregation hasFormat 1940901.dc.
- aggregation hasFormat 1940901.didl.
- aggregation hasFormat 1940901.doc.
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- aggregation hasFormat 1940901.yaml.
- aggregation isPartOf urn:issn:0893-133X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and Tryptophan challenge".
- aggregation abstract "Previous data suggest that a polymorphism at the serotonin (5-HT) transporter gene (5-HTTLPR) may influence stress resilience and stress-related depression symptoms due to interactions between brain 5-HT dysfunction and stress exposure. Although attentional bias for emotional information has been reliably observed in depression, the interaction between 5-HT transporter-linked promoter region (5-HTTLPR), brain 5-HT vulnerability, and acute stress on affective information processing has not yet been investigated. This study examines the effects of tryptophan (TRP) augmentation (indicating 5-HT manipulation) on inhibition of negative emotional information under stress in mainly female S'/S'-vs L'/L'-allele carriers. A total of 15 female homozygotic short-allele 5-HTTLPR (S'/S' S/S, S/L(G), L(G)/L(G)) and 13 female homozygotic long-allele 5-HTTLPR (L'/L' L(A)/L(A)) subjects were tested for mood and inhibition of emotional information in a double-blind, placebo-controlled design before and after stress exposure following TRP manipulation. Stress exposure significantly impaired inhibition of negative affective information only in S'/S' carriers, whereas L'/L' carriers even showed increased inhibition of negative information. The S'/S' allele 5-HTTLPR genotype increases cognitive-attentional bias for negative emotional information under acute stress. As this bias is an important component of depression, this may be a mediating mechanism making S'/S'-allele carriers more vulnerability for stress-induced depression symptoms. Moreover, current data suggest that L'/L'-allele genotypes are more resilient, even increasing cognitive emotional (inhibitory) control after stress. Neuropsychopharmacology (2011) 36, 819-826; doi:10.1038/npp.2010.221; published online 8 December 2010".
- aggregation authorList BK850399.
- aggregation endPage "826".
- aggregation issue "4".
- aggregation startPage "819".
- aggregation volume "36".
- aggregation aggregates 1940908.
- aggregation isDescribedBy 1940901.
- aggregation similarTo npp.2010.221.
- aggregation similarTo LU-1940901.