Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1947818#aggregation> ?p ?o. }
Showing items 1 to 37 of
37
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B314757.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1947818.bibtex.
- aggregation hasFormat 1947818.csv.
- aggregation hasFormat 1947818.dc.
- aggregation hasFormat 1947818.didl.
- aggregation hasFormat 1947818.doc.
- aggregation hasFormat 1947818.json.
- aggregation hasFormat 1947818.mets.
- aggregation hasFormat 1947818.mods.
- aggregation hasFormat 1947818.rdf.
- aggregation hasFormat 1947818.ris.
- aggregation hasFormat 1947818.txt.
- aggregation hasFormat 1947818.xls.
- aggregation hasFormat 1947818.yaml.
- aggregation isPartOf urn:issn:0140-7783.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "The influence of modulation of P-glycoprotein and/or cytochrome P450 3A on the pharmacokinetics and pharmacodynamics of orally administered morphine in dogs".
- aggregation abstract "The influence of pretreatment with ketoconazole [cytochrome P450 3A (CYP3A) + P-glycoprotein (P-gp) inhibitor], elacridar (selective P-gp inhibitor) and rifampicin (CYP3A + P-gp inducer) on oral morphine pharmacokinetics and pharmacodynamics was investigated in experimental dogs. Seven beagles were used in a four-way crossover design. Morphine hydrochloride was administered orally (2.5 mg/kg) alone (control group CON) or after pretreatment with ketoconazole (group KETO), elacridar (group ELA) or rifampicin (group RIF). Morphine plasma concentrations were analysed by liquid chromatography-tandem mass spectrometry. Sedation scores (none, mild, moderate or severe) were evaluated subjectively. Dogs were significantly (P < 0.05) more sedated after ketoconazole pretreatment. There were no significant differences between group CON and the other pretreatment groups in pharmacokinetic parameters taking both sexes into account. Sex differences were apparent in some pharmacokinetic parameters of morphine. The area under the plasma concentration time curve (AUC(0-infinity)) was significantly higher, and the total body clearance was significantly lower in male compared to female dogs in all treatment groups. Ketoconazole, rifampicin and elacridar pretreatment had no significant effects on morphine pharmacokinetics, although dogs in the ketoconazole group showed higher sedation scores.".
- aggregation authorList BK603897.
- aggregation endPage "423".
- aggregation issue "5".
- aggregation startPage "417".
- aggregation volume "34".
- aggregation aggregates 1947826.
- aggregation isDescribedBy 1947818.
- aggregation similarTo j.1365-2885.2010.01264.x.
- aggregation similarTo LU-1947818.