Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1984194#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B404293.
- aggregation creator B404294.
- aggregation creator B404295.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1984194.bibtex.
- aggregation hasFormat 1984194.csv.
- aggregation hasFormat 1984194.dc.
- aggregation hasFormat 1984194.didl.
- aggregation hasFormat 1984194.doc.
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- aggregation hasFormat 1984194.txt.
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- aggregation hasFormat 1984194.yaml.
- aggregation isPartOf urn:issn:0741-5400.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function".
- aggregation abstract "This study tested the hypothesis that V gamma 3 TCR-bearing T cells are influenced by LCs. V gamma 3 T cells and LCs are located in the epidermis of mice. V gamma 3 T cells represent the main T cell population in the skin epithelium and play a crucial role in maintaining the skin integrity, whereas LCs are professional APCs. Although V gamma 3 T cells and LCs form an interdigitating network in the epidermis, not much is known about their reciprocal influence and/or interdependence. We used two different LC-deficient mouse models, in which LCs are constitutively or inducibly depleted, to investigate the role of LCs in maturation, homeostasis, and function of V gamma 3 T cells. We show that V gamma 3 T cell numbers are unaltered by LC deficiency, and V gamma 3 T cells isolated from LC-deficient mice are phenotypically and upon in vitro stimulation, functionally indistinguishable from V gamma 3 T cells isolated from WT mice based on their cytotoxic potential and cytokine production. Additionally, in vivo skin-wounding experiments show no major difference in response of V gamma 3 T cells to wounding in the absence or presence of LCs. These observations indicate that V gamma 3 T cells develop and function independently of LCs".
- aggregation authorList BK716916.
- aggregation endPage "68".
- aggregation issue "1".
- aggregation startPage "61".
- aggregation volume "90".
- aggregation aggregates 1984895.
- aggregation isDescribedBy 1984194.
- aggregation similarTo jlb.1010581.
- aggregation similarTo LU-1984194.