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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1984666.bibtex.
- aggregation hasFormat 1984666.csv.
- aggregation hasFormat 1984666.dc.
- aggregation hasFormat 1984666.didl.
- aggregation hasFormat 1984666.doc.
- aggregation hasFormat 1984666.json.
- aggregation hasFormat 1984666.mets.
- aggregation hasFormat 1984666.mods.
- aggregation hasFormat 1984666.rdf.
- aggregation hasFormat 1984666.ris.
- aggregation hasFormat 1984666.txt.
- aggregation hasFormat 1984666.xls.
- aggregation hasFormat 1984666.yaml.
- aggregation isPartOf urn:issn:0968-5243.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Precision analysis of kinetic modelling estimates in dynamic contrast enhanced MRI".
- aggregation abstract "Dynamic contrast enhanced MRI and pharmacokinetic modelling provide a powerful tool for tumour diagnosis and treatment evaluation. However, several studies show low reproducibility of the technique and poor precision of the transendothelial transfer constant K (trans). This work proposes a theoretical framework describing how finite signal-noise-ratio (SNR) in the MR images is propagated throughout the measurement protocol to uncertainty on the kinetic parameter estimates. After deriving a distribution for the contrast agent concentration, a maximum likelihood estimator (MLM) is proposed that exhibits Cramer-Rao lower bounds (CRLB). An analytical expression is derived for the CRLB that can be used to determine confidence intervals for kinetic parameters and to investigate the influence of protocol parameters as scan time and temporal resolution on K (trans)-precision. K (trans)-uncertainty can be reduced up to 30% by using MLM in comparison with least square estimator. K (trans)-precision is proportional to the SNR and depends strongly on the kinetic parameter values themselves. Minimal scan time and temporal resolution were found to be 15 min and 15 s, respectively, for Gd-DTPA. Temporal resolution should be enhanced by decreasing the NEX parameter (NEX a parts per thousand currency sign 1). CRLB provide a golden standard to construct 95% confidence intervals, which can be used to perform protocol optimization and to test the statistical significance of K (trans)-changes in treatment evaluation.".
- aggregation authorList BK764004.
- aggregation endPage "66".
- aggregation issue "2".
- aggregation startPage "51".
- aggregation volume "24".
- aggregation aggregates 1984753.
- aggregation isDescribedBy 1984666.
- aggregation similarTo s10334-010-0235-6.
- aggregation similarTo LU-1984666.