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- aggregation classification "A1".
- aggregation creator B293170.
- aggregation creator B293171.
- aggregation creator B293172.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2008769.bibtex.
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- aggregation isPartOf urn:issn:0305-1048.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Biology and Life Sciences".
- aggregation title "The microRNA body map: dissecting microRNA function through integrative genomics".
- aggregation abstract "While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of corresponding miRNA and mRNA gene expression levels, miRNA target prediction, transcription factor target prediction and mechanistic models of gene network regulation. Predicted miRNA functions were either validated experimentally or compared to published data. The predicted miRNA functions are accessible in the miRNA bodymap, an interactive online compendium and mining tool of high-dimensional newly generated and published miRNA expression profiles. The miRNA bodymap enables prioritization of candidate miRNAs based on their expression pattern or functional annotation across tissue or disease subgroup. The miRNA bodymap project provides users with a single one-stop data-mining solution and has great potential to become a community resource.".
- aggregation authorList BK578531.
- aggregation issue "20".
- aggregation volume "39".
- aggregation aggregates 3147422.
- aggregation aggregates 3147423.
- aggregation isDescribedBy 2008769.
- aggregation similarTo gkr646.
- aggregation similarTo LU-2008769.