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- aggregation classification "A1".
- aggregation creator B677508.
- aggregation creator B677509.
- aggregation creator B677510.
- aggregation creator B677511.
- aggregation creator B677512.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation hasFormat 2014638.bibtex.
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- aggregation isPartOf urn:issn:0014-2972.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "In the mind or in the brain?: scientific evidence for central sensitisation in chronic fatigue syndrome".
- aggregation abstract "Background Central sensitisation entails several top-down and bottom-up mechanisms, all contributing to the hyperresponsiveness of the central nervous system to a variety of inputs. In the late nineties, it was first hypothesised that chronic fatigue syndrome (CFS) is characterised by hypersensitivity of the central nervous system (i.e. central sensitisation). Since then, several studies have examined central sensitisation in patients with CFS. This study provides an overview of such studies. Materials and Methods Narrative review. Results Various studies showed generalised hyperalgesia in CFS for a variety of sensory stimuli, including electrical stimulation, mechanical pressure, heat and histamine. Various tissues are affected by generalised hyperalgesia: the skin, muscle tissue and the lungs. Generalised hyperalgesia in CFS is augmented, rather than decreased, following various types of stressors like exercise and noxious heat pain. Endogenous inhibition is not activated in response to exercise and activation of diffuse noxious inhibitory controls following noxious heat application to the skin is delayed. Conclusions The observation of central sensitisation in CFS is in line with our current understanding of CFS. The presence of central sensitisation in CFS corroborates with the presence of several psychological influences on the illness, the presence of infectious agents and immune dysfunctions and the dysfunctional hypothalamus-pituitary-adrenal axis as seen in these severely debilitated patients.".
- aggregation authorList BK1041054.
- aggregation endPage "212".
- aggregation issue "2".
- aggregation startPage "203".
- aggregation volume "42".
- aggregation isDescribedBy 2014638.
- aggregation similarTo j.1365-2362.2011.02575.x.
- aggregation similarTo LU-2014638.