Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2017061#aggregation> ?p ?o. }
Showing items 1 to 38 of
38
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B511358.
- aggregation creator B511359.
- aggregation creator B511360.
- aggregation creator B511361.
- aggregation creator B511362.
- aggregation creator B511363.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2017061.bibtex.
- aggregation hasFormat 2017061.csv.
- aggregation hasFormat 2017061.dc.
- aggregation hasFormat 2017061.didl.
- aggregation hasFormat 2017061.doc.
- aggregation hasFormat 2017061.json.
- aggregation hasFormat 2017061.mets.
- aggregation hasFormat 2017061.mods.
- aggregation hasFormat 2017061.rdf.
- aggregation hasFormat 2017061.ris.
- aggregation hasFormat 2017061.txt.
- aggregation hasFormat 2017061.xls.
- aggregation hasFormat 2017061.yaml.
- aggregation isPartOf urn:issn:0269-2813.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Kinetics of butyrate metabolism in the normal colon and in ulcerative colitis: the effects of substrate concentration and carnitine on the b-oxidation pathway".
- aggregation abstract "Background : Butyrate, a colonic metabolite of carbohydrates, is considered as the major energy source for the colonic mucosa. An impaired butyrate metabolism has been reported in ulcerative colitis (UC), however, the cause still remains unknown. Aim : In the present study, we investigated whether higher butyrate concentrations could normalise the oxidation rate in UC. Furthermore, it was investigated whether carnitine could enhance the butyrate oxidation. Methods : Mucosal biopsies from a total of 26 UC patients and 25 controls were incubated with (14)C-labelled Na-butyrate and the produced (14)CO(2) was measured. First, the rate of oxidative metabolism was compared at three different concentrations of Na-butyrate (0.05 mM, 1 mM and 10 mM). Then, incubations of biopsies were performed with carnitine alone or combined with ATP. Results : Overall, butyrate oxidation in UC was significantly lower than that in controls. The maximum rate of butyrate oxidation was achieved in UC and control subjects from 1 mM onwards. Increasing the butyrate concentration to a level to be present in the colonic lumen, i.e. 10 mM, did not increase the rate of butyrate oxidation in UC to the rate observed in controls. Addition of carnitine alone or combined with ATP caused no effects. Conclusions : Saturation of butyrate kinetics was achieved from 1 mM in UC and control subjects. The rate of butyrate metabolism was significantly impaired in active ulcerative colitis. The addition of compounds interfering with the beta-oxidation pathway had no effect on the butyrate metabolism in UC.".
- aggregation authorList BK857412.
- aggregation endPage "532".
- aggregation issue "5".
- aggregation startPage "526".
- aggregation volume "34".
- aggregation aggregates 2017062.
- aggregation isDescribedBy 2017061.
- aggregation similarTo j.1365-2036.2011.04757.x.
- aggregation similarTo LU-2017061.