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- aggregation classification "A1".
- aggregation creator B221842.
- aggregation creator B221843.
- aggregation creator B221844.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2025676.bibtex.
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- aggregation hasFormat 2025676.doc.
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- aggregation isPartOf urn:issn:1757-6180.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Dried blood spot punches for confirmation of suspected γ-hydroxybutyric acid intoxications: validation of an optimized GC-MS procedure".
- aggregation abstract "Background: gamma-hydroxybutyric acid (GHB), notorious as a club-and date-rape drug, was quantified in dried blood spots (DBS) by punching out a disc, followed by 'on-spot' derivatization and ana-lysis by GC-MS. Results: A homogenous distribution in DBS was demonstrated and accurate results were obtained when analyzing a disc punched out from a 20-35 mu l spot, regardless the hematocrit of the blood sample. Validation based on US FDA and European Medicines Agency guidelines was performed, with a calibration range covering 2-100 mu g/ml. Conclusion: A sensitive GC-MS method for GHB ana-lysis in DBS was successfully optimized and validated. The successful ana-lysis of DBS collected from GHB abusers suggests the routine applicability of the DBS sampling technique for GHB ana-lysis in toxicological cases.".
- aggregation authorList BK486511.
- aggregation endPage "2281".
- aggregation issue "20".
- aggregation startPage "2271".
- aggregation volume "3".
- aggregation aggregates 2025823.
- aggregation aggregates 2025824.
- aggregation isDescribedBy 2025676.
- aggregation similarTo BIO.11.204.
- aggregation similarTo LU-2025676.