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- aggregation classification "C3".
- aggregation creator person.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2039089.bibtex.
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- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Plasma serotonin and surgical small intestinal colic in horses".
- aggregation abstract "Introduction: Serotonin (5-hydroxytryptamine) is an important signaling molecule in the body and a major regulator of gastrointestinal motility. It is released in increased quantities in several conditions, including intestinal ischemia-reperfusion and platelet activation. In surgical colic cases, changes in free plasma serotonin could hypothetically contribute to the development of equine postoperative ileus. Therefore plasma serotonin concentrations were compared in healthy horses and horses undergoing laparotomy for small intestinal colic. Materials and Methods: a total of 164 EDTA plasma samples were collected from 24 control horses and 34 colic horses. Samples from the colic horses were collected at admission, immediately after surgery and at least the first morning postoperatively. Platelet stabilizing agents aspirin (1 mM), clomipramine (1 µM) and phenelzine (10 µM) were added and samples were centrifuged to produce platelet poor plasma. Serotonin concentrations were determined with a validated liquid chromatography tandem mass spectrometry method (LC-MS/MS). Serotonin differences were analyzed using logistic regression. Results: Small intestinal surgical colic cases had significantly lower plasma serotonin concentrations than healthy horses (n = 55; p < 0.001; OR 0.96; 95% CI 0.94-0.98) at admission, with a trend towards lower concentrations postoperatively (n = 55; p = 0.08) and the next morning (n = 55; p = 0.08). Within the group of colic horses, there was no difference in plasma serotonin at admission between horses that developed ileus and horses with a normal intestinal recovery (n = 27; p = 0.91), nor between horses that survived to discharge and non-survivors (n = 31; p = 0.89). Conclusions: Plasma serotonin concentrations were lower in surgical small intestinal colic horses. There was no relation to development of ileus or postoperative survival. Variable results have been published concerning serotonin values in healthy and diseased horses. More studies using standardized sampling protocols and reliable measurement methods are needed.".
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