Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2056292#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2056292.bibtex.
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- aggregation isPartOf urn:issn:1944-0049.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens".
- aggregation abstract "In this study, three new models were developed for efficacy testing of mycotoxin detoxifying agents in relation to recent European guidelines. In the first model, deoxynivalenol was given to broiler chickens as an intra-crop bolus together with a mycotoxin detoxifying agent in order to study the plasma concentration-time profile of deoxynivalenol. In the second model the same oral bolus was given, preceded by an oral bolus of mycotoxin detoxifying agent, to make sure the detoxifying agent was present in the whole intestinal tract when the mycotoxin was administered. In the third model, the mycotoxin detoxifying agent was mixed in the feed of broiler chickens, and after one week feeding, deoxynivalenol was given as an oral bolus. In order to evaluate the efficacy of these agents, plasma concentration-time profiles were set up and the main toxicokinetic parameters were compared. Two commercially available mycotoxin detoxifying agents were tested, but they were not able to lower the oral availability of deoxynivalenol. As a positive control, activated carbon was used. We showed that activated carbon significantly reduces the absorption and oral availability of deoxynivalenol in all three models. Therefore, it can be concluded that these models are able to demonstrate the efficacy of mycotoxin detoxifying agents in relation to EFSA guidelines.".
- aggregation authorList BK722685.
- aggregation endPage "1107".
- aggregation issue "7".
- aggregation startPage "1101".
- aggregation volume "29".
- aggregation aggregates 2984669.
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- aggregation similarTo 19440049.2012.671788.
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