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- aggregation classification "A1".
- aggregation creator B109178.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "1992".
- aggregation format "application/pdf".
- aggregation hasFormat 206936.bibtex.
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- aggregation isPartOf urn:issn:0047-6374.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat".
- aggregation abstract "The influence of age on stereoselective pharmacokinetics and in vitro metabolism of R- and S-hexobarbital was studied in the rat. After intravenous administration of the racemate, the plasma concentrations of S-hexobarbital are markedly lower than those of R-hexobarbital. For S-hexobarbital the half-life is somewhat shorter and the volume of distribution and plasma clearance is higher than for its antipode. For both enantiomers an increase in AUC and half-life, and a decrease in clearance are observed with aging. These changes occur mainly between the 3rd and the 12th month and are slightly more pronounced for R- than for S-hexobarbital, as appears from the SIR ratios. The volume of distribution shows no changes with aging. In vitro disappearance rate in 3-month-old rats is significantly higher for S- than for R-hexobarbital. There is for both enantiomers an increase in disappearance rate in 12-month-old rats as compared to younger or older rats, but this is significant only for the R-enantiomer. There are pronounced differences in the kinetics and metabolism of both hexobarbital enantiomers; changes with aging occur, but are only slightly and not always significantly more important for R- than for S-hexobarbital.".
- aggregation authorList BK279246.
- aggregation endPage "175".
- aggregation issue "2-3".
- aggregation startPage "167".
- aggregation volume "65".
- aggregation aggregates 4208026.
- aggregation isDescribedBy 206936.
- aggregation similarTo 0047-6374(92)90033-A.
- aggregation similarTo LU-206936.