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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation date "1992".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:0014-2999.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Influence of age on responsiveness of rat gastric fundus to agonists and to stimulation of intrinsic nerves".
- aggregation abstract "The contractile effect of methacholine, prostaglandin F2alpha (PGF2alpha) and electrical stimulation of cholinergic neurones, and the relaxant effect of nitric oxide (NO), vasoactive intestinal polypeptide (VIP) and electrical stimulation of inhibitory non-adrenergic non-cholinergic (NANC) neurones were studied in longitudinal smooth muscle strips of the gastric fundus of young (3 months), adult (12 months) and old (24 months) male Wistar rats. The contractile responses to methacholine and to electrical stimulation of cholinergic neurones were not significantly different between the three age groups. The responses to PGF2alpha were significantly more pronounced in young than in adult and old rats. The relaxant response to electrical stimulation of NANC neurones with a cumulative increase in frequency showed a decreased response in old rats at the higher stimulation frequencies. This was mimicked by a decreased response to VIP, suggesting that there is a decrease in muscular sensitivity to VIP rather than an impaired capacity to VIP release with increasing age. The relaxant response to electrical stimulation of NANC neurones with short trains was similar in the three age groups, while the sensitivity to exogenous NO increased with age. The latter might be a compensatory mechanism for a decrease in stimulation-induced NO release with age.".
- aggregation authorList BK169388.
- aggregation endPage "102".
- aggregation issue "1".
- aggregation startPage "97".
- aggregation volume "223".
- aggregation aggregates 4207906.
- aggregation isDescribedBy 207295.
- aggregation similarTo 0014-2999(92)90823-M.
- aggregation similarTo LU-207295.