Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2075240#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B254821.
- aggregation creator B254822.
- aggregation creator B254823.
- aggregation creator B254824.
- aggregation creator B254825.
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- aggregation creator B254829.
- aggregation creator B254830.
- aggregation creator B254831.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2075240.bibtex.
- aggregation hasFormat 2075240.csv.
- aggregation hasFormat 2075240.dc.
- aggregation hasFormat 2075240.didl.
- aggregation hasFormat 2075240.doc.
- aggregation hasFormat 2075240.json.
- aggregation hasFormat 2075240.mets.
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- aggregation hasFormat 2075240.rdf.
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- aggregation hasFormat 2075240.txt.
- aggregation hasFormat 2075240.xls.
- aggregation hasFormat 2075240.yaml.
- aggregation isPartOf urn:issn:0270-9139.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry".
- aggregation abstract "Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Current antiviral therapy fails to clear infection in a substantial proportion of cases. Drug development is focused on nonstructural proteins required for RNA replication. Individuals undergoing orthotopic liver transplantation face rapid, universal reinfection of the graft. Therefore, antiviral strategies targeting the early stages of infection are urgently needed for the prevention of HCV infection. In this study, we identified the polyphenol, epigallocatechin-3-gallate (EGCG), as an inhibitor of HCV entry. Green tea catechins, such as EGCG and its derivatives, epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC), have been previously found to exert antiviral and antioncogenic properties. EGCG had no effect on HCV RNA replication, assembly, or release of progeny virions. However, it potently inhibited Cell-culture-derived HCV (HCVcc) entry into hepatoma cell lines as well as primary human hepatocytes. The effect was independent of the HCV genotype, and both infection of cells by extracellular virions and cell-to-cell spread were blocked. Pretreatment of cells with EGCG before HCV inoculation did not reduce HCV infection, whereas the application of EGCG during inoculation strongly inhibited HCV infectivity. Moreover, treatment with EGCG directly during inoculation strongly inhibited HCV infectivity. Expression levels of all known HCV (co-) receptors were unaltered by EGCG. Finally, we showed that EGCG inhibits viral attachment to the cell, thus disrupting the initial step of HCV cell entry. Conclusion: The green tea molecule, EGCG, potently inhibits HCV entry and could be part of an antiviral strategy aimed at the prevention of HCV reinfection after liver transplantation".
- aggregation authorList BK528126.
- aggregation endPage "1955".
- aggregation issue "6".
- aggregation startPage "1947".
- aggregation volume "54".
- aggregation aggregates 2082487.
- aggregation isDescribedBy 2075240.
- aggregation similarTo hep.24610.
- aggregation similarTo LU-2075240.