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- aggregation classification "A1".
- aggregation creator B293654.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2100466.bibtex.
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- aggregation isPartOf urn:issn:0021-9533.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia".
- aggregation abstract "It is generally accepted that the intercalated disc (ICD) required for mechano-electrical coupling in the heart consists of three distinct junctional complexes: adherens junctions, desmosomes and gap junctions. However, recent morphological and molecular data indicate a mixing of adherens junctional and desmosomal components, resulting in a 'hybrid adhering junction' or 'area composita'. The alpha-catenin family member alpha T-catenin, part of the N-cadherin-catenin adhesion complex in the heart, is the only alpha-catenin that interacts with the desmosomal protein plakophilin-2 (PKP2). Thus, it has been postulated that alpha T-catenin might serve as a molecular integrator of the two adhesion complexes in the area composita. To investigate the role of alpha T-catenin in the heart, gene targeting technology was used to delete the Ctnna3 gene, encoding alpha T-catenin, in the mouse. The alpha T-catenin-null mice are viable and fertile; however, the animals exhibit progressive cardiomyopathy. Adherens junctional and desmosomal proteins were unaffected by loss of alpha T-catenin, with the exception of the desmosomal protein PKP2. Immunogold labeling at the ICD demonstrated in the alpha T-catenin-null heart a preferential reduction of PKP2 at the area composita compared with the desmosome. Furthermore, gap junction protein Cx43 was reduced at the ICD, including its colocalization with N-cadherin. Gap junction remodeling in alpha T-catenin-knockout hearts was associated with an increased incidence of ventricular arrhythmias after acute ischemia. This novel animal model demonstrates for the first time how perturbation in alpha T-catenin can affect both PKP2 and Cx43 and thereby highlights the importance of understanding the crosstalk between the junctional proteins of the ICD and its implications for arrhythmogenic cardiomyopathy.".
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- aggregation endPage "1067".
- aggregation issue "4".
- aggregation startPage "1058".
- aggregation volume "125".
- aggregation aggregates 2100510.
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