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- aggregation classification "A1".
- aggregation creator B453951.
- aggregation creator B453952.
- aggregation creator B453953.
- aggregation creator B453954.
- aggregation creator B453955.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2122745.bibtex.
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- aggregation isPartOf urn:issn:0006-341X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Mathematics and Statistics".
- aggregation title "Combining disease models to test for gene-environment interaction in nuclear families".
- aggregation abstract "It is useful to have robust geneenvironment interaction tests that can utilize a variety of family structures in an efficient way. This article focuses on tests for geneenvironment interaction in the presence of main genetic and environmental effects. The objective is to develop powerful tests that can combine trio data with parental genotypes and discordant sibships when parents' genotypes are missing. We first make a modest improvement on a method for discordant sibs (discordant on phenotype), but the approach does not allow one to use families when all offspring are affected, e.g., trios. We then make a modest improvement on a Mendelian transmission-based approach that is inefficient when discordant sibs are available, but can be applied to any nuclear family. Finally, we propose a hybrid approach that utilizes the most efficient method for a specific family type, then combines over families. We utilize this hybrid approach to analyze a chronic obstructive pulmonary disorder dataset to test for geneenvironment interaction in the Serpine2 gene with smoking. The methods are freely available in the R package fbati.".
- aggregation authorList BK790068.
- aggregation endPage "1270".
- aggregation issue "4".
- aggregation startPage "1260".
- aggregation volume "67".
- aggregation aggregates 3147249.
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- aggregation similarTo j.1541-0420.2011.01581.x.
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