Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2126027#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B453702.
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- aggregation date "2008".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:0028-0836.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "An intrinsic mechanism of corticogenesis from embryonic stem cells".
- aggregation abstract "The cerebral cortex develops through the coordinated generation of dozens of neuronal subtypes, but the mechanisms involved remain unclear. Here we show that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons. When grafted into the cerebral cortex, these neurons develop patterns of axonal projections corresponding to a wide range of cortical layers, but also to highly specific cortical areas, in particular visual and limbic areas, thereby demonstrating that the identity of a cortical area can be specified without any influence from the brain. The discovery of intrinsic corticogenesis sheds new light on the mechanisms of neuronal specification, and opens new avenues for the modelling and treatment of brain diseases.".
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- aggregation endPage "357".
- aggregation issue "7211".
- aggregation startPage "351".
- aggregation volume "455".
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