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- aggregation classification "A1".
- aggregation creator B35150.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2003".
- aggregation format "application/pdf".
- aggregation hasFormat 212718.bibtex.
- aggregation hasFormat 212718.csv.
- aggregation hasFormat 212718.dc.
- aggregation hasFormat 212718.didl.
- aggregation hasFormat 212718.doc.
- aggregation hasFormat 212718.json.
- aggregation hasFormat 212718.mets.
- aggregation hasFormat 212718.mods.
- aggregation hasFormat 212718.rdf.
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- aggregation hasFormat 212718.txt.
- aggregation hasFormat 212718.xls.
- aggregation hasFormat 212718.yaml.
- aggregation isPartOf urn:issn:0730-7268.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Testosterone metabolism in the estuarine mysid Neomysis integer (Crustacea: Mysidacea) following tributyltin exposure".
- aggregation abstract "Current evidence suggests that the biocide tributyltin (TBT) causes the development of imposex, a state of pseudohermaphrodism in which females exhibit functional secondary male characteristics, by altering the biotransformation or elimination of testosterone. Imposex in gastropods following TBT exposure is the most complete example of the effects of an endocrine disrupter on marine invertebrates. Previous studies have demonstrated that the estuarine mysid Neomysis integer converts testosterone into multiple polar and nonpolar metabolites resulting from both phase I and phase II biotransformations. In this study, the effects of TBT chloride (TBTCl) on the phase I and II testosterone metabolism of N. integer were evaluated. The TBTCl was highly toxic to N. integer (96-h median lethal concentration [LC50] of 164 ng/L). To assess the effects on testosterone metabolism, mysids were exposed for 96 h to different concentrations of TBTCl (control, 10, 100, and 1,000 ng/L), and testosterone elimination as polar hydroxylated, nonpolar oxido-reduced, and glucose- and sulfate-conjugated metabolites was examined. The TBTCl differentially affected testosterone metabolism. The effect of TBTCl on phase I metabolism was unclear and has been shown to vary among species, likely depending on the inducibility or presence of certain P450 isozyme families. Reductase activity and metabolic androgenization were induced in the 10-ng/L treatment, whereas higher concentrations resulted in a reduction of sulfate conjugation. The exact mechanisms underlying TBT-induced imposex and alterations in the steroid metabolism need to be further elucidated.".
- aggregation authorList BK89033.
- aggregation endPage "2036".
- aggregation issue "9".
- aggregation startPage "2030".
- aggregation volume "22".
- aggregation aggregates 1889035.
- aggregation isDescribedBy 212718.
- aggregation similarTo etc.5620220910.
- aggregation similarTo LU-212718.