Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2129204#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B455040.
- aggregation creator B455041.
- aggregation creator B455042.
- aggregation creator B455043.
- aggregation creator B455044.
- aggregation creator B455045.
- aggregation creator B455046.
- aggregation creator B455047.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2129204.bibtex.
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- aggregation isPartOf urn:issn:1860-7179.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Chemistry".
- aggregation title "Asymmetric synthesis and conformational analysis by NMR spectroscopy and MD of Aba- and α-MeAba-containing dermorphin analogues".
- aggregation abstract "Dermorphin analogues, containing a (S)- and (R)-4-amino1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold (Aba) and the alpha-methylated analogues as conformationally constrained phenylalanines, were prepared. Asymmetric phase-transfer catalysis was unable to provide the (S)-alpha-Me-o-cyanophenylalanine precursor for (S)-alpha-MeAba in acceptable enantiomeric purity. However, by using a Schollkopf chiral auxiliary, this intermediate was obtained in 88% ee. [(S)-Aba 3-Gly 4] dermorphin retained mu-opioid affinity but displayed an increased delta-affinity. The corresponding R epimer was considerably less potent. In contrast, the [(R)-alpha-MeAba3-Gly4] dermorphin isomer was more potent than its S epimer. Tar-MD simulations of both non-methylated [Aba 3-Gly 4] dermorphin analogues showed a degree of folding at the C-terminal residues toward the N terminus of the peptide, without however, adopting a stabilized beta-turn conformation. The alpha-methylated analogues, on the other hand, exhibited a type I/I' beta-turn conformation over the alpha-MeAba3 and Gly4 residues, which was stabilized by a hydrogen bond involving Tyr5-H(N) and D-Ala 2-CO.".
- aggregation authorList BK792243.
- aggregation endPage "2047".
- aggregation issue "11".
- aggregation startPage "2035".
- aggregation volume "6".
- aggregation aggregates 2134032.
- aggregation isDescribedBy 2129204.
- aggregation similarTo cmdc.201100314.
- aggregation similarTo LU-2129204.