Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2132838#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B452404.
- aggregation creator B452405.
- aggregation creator person.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2132838.bibtex.
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- aggregation isPartOf urn:issn:0194-911X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Arterial properties as determinants of time-varying myocardial stress in humans".
- aggregation abstract "Myocardial and arterial load are time-varying phenomena. Despite their importance in myocardial function, the arterial properties that determine time-resolved myocardial wall stress are unknown. We aimed to assess arterial properties as determinants of time-resolved myocardial stress among 1,214 men and women enrolled in the Asklepios study. Time-resolved central pressure, flow and left ventricular (LV) geometry were measured with carotid tonometry, Doppler and speckle-tracking echocardiography, respectively, for computation of arterial load and ejection-phase time-varying myocardial wall stress. For any given end-diastolic LV geometry and cardiac output, peak myocardial stress correlated directly with systemic vascular resistance (SVR; Standardized β=1.12; P<0.0001) and aortic characteristic impedance (Std β=0.17; P<0.0001). The ejection-phase stress-time integral correlated with SVR (Std β=1.06; P<0.0001), lower total arterial compliance (Std β=-0.13; P=0.0008) and earlier return of wave reflections (Std β=-0.10; P<0.0001) but not with reflection magnitude, whereas end-systolic wall stress correlated with SVR (Std β=1.06; P<0.0001) and reflection magnitude (Std β=0.12; P<0.0001). After adjustment for age, all measured arterial properties, end-diastolic LV geometry and cardiac output, women demonstrated greater peak (534 vs. 507 kdynes/cm2; P<0.0001), end-systolic (335 vs. 320 kdynes/cm2; P<0.0001) and ejection-phase stress-time integral (157 vs. 142 kdyne•s•cm-2; P<0.0001). In conclusion, different arterial properties have selective effects on time-resolved ejection-phase myocardial wall stress, which are not apparent from single-time point measurements. Women demonstrate less efficient myocardial-arterial coupling, with higher wall stress development for any given LV geometry, arterial properties and flow output. These observations may relate to the differential susceptibility of women to heart failure.".
- aggregation authorList BK787512.
- aggregation endPage "70".
- aggregation issue "1".
- aggregation startPage "64".
- aggregation volume "60".
- aggregation aggregates 2132877.
- aggregation aggregates 2132879.
- aggregation aggregates 2132902.
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- aggregation similarTo HYPERTENSIONAHA.112.190710.
- aggregation similarTo LU-2132838.