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- aggregation classification "A1".
- aggregation creator B453882.
- aggregation creator B453883.
- aggregation creator B453884.
- aggregation creator B453885.
- aggregation creator B453886.
- aggregation creator B453887.
- aggregation creator B453888.
- aggregation creator B453889.
- aggregation creator B453890.
- aggregation creator B453891.
- aggregation creator B453892.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2140399.bibtex.
- aggregation hasFormat 2140399.csv.
- aggregation hasFormat 2140399.dc.
- aggregation hasFormat 2140399.didl.
- aggregation hasFormat 2140399.doc.
- aggregation hasFormat 2140399.json.
- aggregation hasFormat 2140399.mets.
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- aggregation hasFormat 2140399.rdf.
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- aggregation hasFormat 2140399.txt.
- aggregation hasFormat 2140399.xls.
- aggregation hasFormat 2140399.yaml.
- aggregation isPartOf urn:issn:1932-6203.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy".
- aggregation abstract "Photochemotherapy is used both for solid tumors and in extracorporeal treatment of various hematologic disorders. Nevertheless, its development in oncology remains limited, because of the low selectivity of photosensitizers (PS) towards human tumor cells. To enhance PS efficiency, we recently covalently linked a porphyrin (TrMPyP) to a plant lectin (Morniga G), known to recognize with high affinity tumor-associated T and Tn antigens. The conjugation allowed a quick uptake of PS by Tn-positive Jurkat leukemia cells and efficient PS-induced phototoxicity. The present study was performed: (i) to evaluate the targeting potential of the conjugate towards tumor and normal cells and its phototoxicity on various leukemia cells, (ii) to investigate the mechanism of conjugate-mediated cell death. The conjugate: (i) strongly increased (x1000) the PS phototoxicity towards leukemic Jurkat T cells through an O-glycan-dependent process; (ii) specifically purged tumor cells from a 1:1 mixture of Jurkat leukemia (Tn-positive) and healthy (Tn-negative) lymphocytes, preserving the activation potential of healthy lymphocytes; (iii) was effective against various leukemic cell lines with distinct phenotypes, as well as fresh human primary acute and chronic lymphoid leukemia cells; (iv) induced mostly a caspase-independent cell death, which might be an advantage as tumor cells often resist caspase-dependent cell death. Altogether, the present observations suggest that conjugation with plant lectins can allow targeting of photosensitizers towards aberrant glycosylation of tumor cells, e. g. to purge leukemia cells from blood and to preserve the normal leukocytes in extracorporeal photochemotherapy.".
- aggregation authorList BK789944.
- aggregation issue "8".
- aggregation volume "6".
- aggregation aggregates 3145582.
- aggregation isDescribedBy 2140399.
- aggregation similarTo journal.pone.0023315.
- aggregation similarTo LU-2140399.