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- aggregation classification "A1".
- aggregation creator B255573.
- aggregation creator person.
- aggregation creator person.
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- aggregation creator person.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2152777.bibtex.
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- aggregation hasFormat 2152777.yaml.
- aggregation isPartOf urn:issn:0161-5505.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "99mTc-labeled tricarbonyl His-CNA35 as an imaging agent for the detection of tumor vasculature".
- aggregation abstract "Given the importance of angiogenesis for a tumor's survival and growth, several therapeutic strategies rely on the selective inhibition of angiogenesis and the destruction of existing tumor vasculature. These strategies raise the need for a noninvasive tool to evaluate tumor vasculature. We describe the radiosynthesis and evaluation of an imaging tracer that specifically binds tumor subendothelial collagen and thereby images tumor vasculature. Methods: Tc-99m-tricarbonyl was prepared and labeled with His-collagen-binding adhesion protein 35 (CNA35). After in vitro specificity testing, in vivo biodistribution and dosimetric studies were performed in healthy nude mice via planar imaging. Tc-99m-(CO)(3) His-CNA35 was evaluated for in vivo imaging of tumor vasculature in a HT29 colorectal carcinoma xenograft. Results: The labeling procedure yielded a compound with 95%-99% radiochemical purity and good in vitro stability. An in vitro binding test confirmed specificity and functionality. Tc-99m-(CO)(3) His-CNA35 rapidly cleared from the blood and pre-dominantly accumulated in the kidneys and liver. The effective dose for a proposed single injection of 500 MBq of Tc-99m-(CO)(3) His-CNA35 is 3.70 mSv per organ or 2.01 mSv/g of tissue. Tumors were successfully visualized, and uptake correlated with ex vivo immunohistochemical staining of tumor vasculature. Conclusion: Tc-99m-(CO)(3) His-CNA35 may be a useful radioligand for the in vivo detection of tumor vasculature through subendothelial collagen binding. A noninvasive method of imaging tumor vasculature that could provide a reliable assessment of tumor vasculature would allow evaluation of the effectiveness of commonly used antiangiogenic therapies and determination of their optimal dosing and scheduling.".
- aggregation authorList BK529753.
- aggregation endPage "471".
- aggregation issue "3".
- aggregation startPage "464".
- aggregation volume "53".
- aggregation aggregates 2951223.
- aggregation isDescribedBy 2152777.
- aggregation similarTo jnumed.111.095794.
- aggregation similarTo LU-2152777.