Matches in UGent Biblio for { <https://biblio.ugent.be/publication/218206#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B134868.
- aggregation creator B134869.
- aggregation creator B134870.
- aggregation creator person.
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- aggregation date "2003".
- aggregation format "application/pdf".
- aggregation hasFormat 218206.bibtex.
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- aggregation hasFormat 218206.dc.
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- aggregation hasFormat 218206.txt.
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- aggregation hasFormat 218206.yaml.
- aggregation isPartOf urn:issn:0105-4538.
- aggregation language "eng".
- aggregation publisher "BLACKWELL MUNKSGAARD".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis".
- aggregation abstract "Background: Alternative splicing of the interleukin-5 receptor alpha (IL-5Ralpha )-subunit leads to the generation of a signalling, membrane-anchored (TM) isoform, or a secreted [soluble (SOL)], antagonistic variant. Given the key role of IL-5 in eosinophil function, we investigated SOL IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP). Methods: An SOL IL-5Ralpha enzyme-linked immunosorbent assay and quantitative real-time polymerase chain reaction (PCR) were established and applied in serum, nasal secretion and nasal tissue of controls (n = 12), and NP patients (n = 42) with or without asthma. Results: Analysis of serum, nasal secretion, and nasal tissue samples revealed that SOL IL-5Ralpha protein concentrations were significantly increased in NP vs control tissue. Within the NP group, there was a significant up-regulation of SOL IL-5Ralpha in patients with systemic airway disease. These findings were confirmed at the mRNA level, using an optimized real-time reverse-transcriptase PCR procedure. Conclusions: This report demonstrates SOL IL-5Ralpha transcript and protein up-regulation in NP. Soluble IL-5Ralpha differentiates nasal polyps with or without concomitant asthma. As SOL IL-5Ralpha is strongly up-regulated for disease and has antagonistic properties in vitro , our studies shed new light on the mechanisms of specific immunomodulatory therapies, such as anti-IL-5.".
- aggregation authorList BK344967.
- aggregation endPage "379".
- aggregation issue "5".
- aggregation startPage "371".
- aggregation volume "58".
- aggregation aggregates 3113822.
- aggregation isDescribedBy 218206.
- aggregation similarTo LU-218206.