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- aggregation classification "A1".
- aggregation creator B168865.
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- aggregation creator B168881.
- aggregation creator B168882.
- aggregation date "1997".
- aggregation hasFormat 270961.bibtex.
- aggregation hasFormat 270961.csv.
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- aggregation hasFormat 270961.didl.
- aggregation hasFormat 270961.doc.
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- aggregation hasFormat 270961.txt.
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- aggregation isPartOf urn:issn:0140-6736.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Randomised double blind comparison of placebo and active treatment for older patients with isolated systolic hypertension".
- aggregation abstract "Background Isolated systolic hypertension occurs in about 15% of people aged 60 years or older. In 1989, the European Working Party on High Blood Pressure whether active treatment investigated cardiovascular complications hypertension. Fatal and non-fatal stroke combined was the primary endpoint. Methods All patients (greater than or equal to 60 years) were initially started on masked placebo. At three run-in visits 1 month apart, their average sitting systolic blood pressure was 160-219 mm Hg with a diastolic blood pressure lower than 95 mm Hg. After stratification for centre, sex, and previous cardiovascular complications, 4695 patients were randomly assigned to nitrendipine 10-40 mg daily, with the possible addition of enalapril 5-20 mg daily and hydrochlorothiazide 12.5-25.0 mg daily, or matching placebos. Patients withdrawing from double-blind treatment were still followed up. We compared occurrence of major endpoints by intention to treat. Findings At a median of 2 years' follow-up, sitting systolic acid diastolic blood pressures had fallen by 13 mm Hg and 2 mm Hg in the placebo group (n=2297) and by 23 mm Hg and 7 mm Hg in the active treatment group (n=2398). The between-group differences were systolic 10.1 mm Hg (95% CI 8.8-11.4) and diastolic, 4.5 mm Hg (3.9-5.1). Active treatment reduced the total rate of stroke from 13.7 to 7.9 endpoints per 1000 patient-years (42% reduction; p=0.003). Non-fatal stroke decreased by 44% (p=0.007). In the active treatment. group, all fatal and non-fatal cardiac endpoints, including sudden death, declined by 26% (p=0.03). Non-fatal cardiac endpoints decreased by 33% (p=0.03) and all fatal and non-fatal cardiovascular endpoints by 31% (p<0.001). Cardiovascular mortality was slightly lower on active treatment (-27%, p=0.07), but all-cause mortality was not influenced (-14%; p=0.22). Interpretation Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications. Treatment of 1000 patients for 5 years with this type of regimen may prevent 29 strokes or 53 major cardiovascular endpoints.".
- aggregation authorList BK416504.
- aggregation endPage "764".
- aggregation issue "9080".
- aggregation startPage "757".
- aggregation volume "350".
- aggregation isDescribedBy 270961.
- aggregation similarTo S0140-6736(97)05381-6.
- aggregation similarTo LU-270961.