Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2753499#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B595074.
- aggregation creator B595075.
- aggregation creator B595076.
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- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2753499.bibtex.
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- aggregation isPartOf urn:issn:0091-6749.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "A novel intranasal therapy of azelastine with fluticasone for the treatment of allergic rhinitis".
- aggregation abstract "Background: Moderate-to-severe allergic rhinitis (AR) is a challenge to treat, with many patients using multiple therapies and achieving limited symptom control. More effective therapies must be developed and tested in well-controlled, randomized, prospective studies with a direct comparison to current standards. Objectives: The aim of these studies was to investigate the efficacy of MP29-02 (a novel formulation of azelastine and fluticasone propionate [FP]) in patients with moderate-to-severe seasonal allergic rhinitis (SAR) and to compare its efficacy with 2 first-line therapies (ie, intranasal azelastine and intranasal FP) in this population. Methods: Three thousand three hundred ninety-eight patients (>= 12 years old) with moderate-to-severe SAR were enrolled into 3 multicenter, randomized, double-blind, placebo-and active-controlled, parallel-group trials (MP4002 [NCT00651118], MP4004 [NCT00740792], and MP4006 [NCT00883168]). Each trial was conducted for 14 days during different allergy seasons. The primary efficacy variable was the sum of the morning and evening change from baseline in reflective total nasal symptom score (range, 0-24) over the treatment period. Outcomes for the meta-analysis included efficacy according to disease severity and time to response in relevant responder criteria. Results: In the meta-analysis MP29-02 reduced the mean reflective total nasal symptom score from baseline (-5.7 [SD, 5.3]) more than FP (-5.1 [SD, 4.9], P < .001), azelastine (-4.4 [SD, 4.8], P < .001), or placebo (-3.0 [SD, 4.2], P < .001). This benefit was observed from the first day of assessment, with improvement in each individual nasal symptom, even in the patients with the most severe disease. MP29-02 achieved response consistently days earlier and showed greater efficacy in patients with moderate-to-severe rhinitis than FP and azelastine. Conclusions: MP29-02 represents a novel therapy that demonstrated superiority to 2 first-line therapies for AR. Patients with moderate-to-severe SAR achieved better control, and their symptoms were controlled earlier with MP29-02 than with recommended medications according to guidelines.".
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- aggregation endPage "1289".
- aggregation issue "5".
- aggregation startPage "1282".
- aggregation volume "129".
- aggregation aggregates 2927541.
- aggregation isDescribedBy 2753499.
- aggregation similarTo j.jaci.2012.01.077.
- aggregation similarTo LU-2753499.