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- aggregation classification "A1".
- aggregation creator B146105.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2003".
- aggregation hasFormat 287234.bibtex.
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- aggregation isPartOf urn:issn:1529-7322.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Superantigens and nasal polyps".
- aggregation abstract "Nasal polyps represent an often severe T-cell-orchestrated eosinophilic upper airway disease with currently unknown pathogenesis, often associated with lower airway disease, such as asthma. Superantigens, predominantly derived from Staphylococcus aureus, are potent activators of T cells, induce the synthesis of IgE in B cells, and have direct effects on pro-inflammatory cells, such as eosinophils. IgE antibodies to S. aureus enterotoxins have been described in polyp tissue, linked to a local polyclonal IgE production and an aggravation of eosinophilic inflammation. Furthermore, such IgE antibodies have also been described in the sera of patients with asthma, and linked to severity of disease and steroid insensitivity. This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis.".
- aggregation authorList BK369135.
- aggregation endPage "531".
- aggregation issue "6".
- aggregation startPage "523".
- aggregation volume "3".
- aggregation isDescribedBy 287234.
- aggregation similarTo s11882-003-0065-y.
- aggregation similarTo LU-287234.