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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2003".
- aggregation format "application/pdf".
- aggregation hasFormat 289821.bibtex.
- aggregation hasFormat 289821.csv.
- aggregation hasFormat 289821.dc.
- aggregation hasFormat 289821.didl.
- aggregation hasFormat 289821.doc.
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- aggregation hasFormat 289821.txt.
- aggregation hasFormat 289821.xls.
- aggregation hasFormat 289821.yaml.
- aggregation isPartOf urn:issn:0928-4249.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils".
- aggregation abstract "Following activation of granulocytes, L-selectin (CD62L) is generally shed from the cellular surface, whereas Mac-1 (CD11b/CD18) expression is well known to increase. However, a number of studies in bovines and humans show that the expression of L-selectin may increase as well. This urged us to examine the possible existence of both L-selectin and Mac-1 reservoirs in bovine neutrophil and eosinophil populations through the use of flow cytometry in combination with an optimized method for cell membrane permeabilization. Augmented L-selectin and Mac-1 expression was detected in both granulocyte populations upon saponin treatment. Confocal microscopic studies indicated that both molecules exhibit a different pattern of subcellular localization. Incubation with sialidase revealed the existence of hidden L-selectin epitopes at the cell surface, while no additional Mac-1 epitopes were exposed. Platelet-activating factor stimulation decreased surface and total expression of L-selectin to the same extent in both populations, but solely affected Mac-1 surface expression on eosinophils. Moreover, cytoskeletal actin filaments and microtubules were found to be involved in the regulation of Mac-1 surface expression on bovine neutrophils and eosinophils. In marked contrast, expression of L-selectin was minimally affected by cytoskeleton perturbing agents. The present study indicates that L-selectin and Mac-1 adhesion molecules reside in distinctly located reservoirs in bovine granulocytes and can be selectively mobilized upon in vitro stimulation.".
- aggregation authorList BK385597.
- aggregation endPage "70".
- aggregation issue "1".
- aggregation startPage "57".
- aggregation volume "34".
- aggregation aggregates 846316.
- aggregation isDescribedBy 289821.
- aggregation similarTo vetres:2002053.
- aggregation similarTo LU-289821.