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- aggregation classification "A1".
- aggregation creator B603781.
- aggregation creator B603782.
- aggregation creator B603783.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 2915878.bibtex.
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- aggregation hasFormat 2915878.dc.
- aggregation hasFormat 2915878.didl.
- aggregation hasFormat 2915878.doc.
- aggregation hasFormat 2915878.json.
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- aggregation hasFormat 2915878.yaml.
- aggregation isPartOf urn:issn:1619-7070.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Improved quantification in single-pinhole and multiple-pinhole SPECT using micro-CT information".
- aggregation abstract "The purpose of this study was to demonstrate the feasibility of accurate quantification in pinhole SPECT using micro-CT information. Pinhole SPECT scans were performed using a clinical dual-head gamma camera. Each pinhole SPECT scan was followed by a micro-CT acquisition. Functional and anatomical images were coregistered using six point sources visible with both modalities. Pinhole SPECT images were reconstructed iteratively. Attenuation correction was based on micro-CT information. Scatter correction was based on dual and triple-energy window methods. Phantom and animal experiments were performed. A phantom containing nine vials was filled with different concentrations of (99m)Tc. Three vials were also filled with CT contrast agent to increase attenuation. Activity concentrations measured on the pinhole SPECT images were compared with activity concentrations measured by the dose calibrator. In addition, 11 mice were injected with (99m)Tc-labelled Nanobodies. After acquiring functional and anatomical images, the animals were killed and the liver activity was measured using a gamma-counter. Activity concentrations measured on the reconstructed images were compared with activity concentrations measured with the gamma counter. The phantom experiments demonstrated an average error of -27.3 +/- 15.9% between the activity concentrations measured on the uncorrected pinhole SPECT images and in the dose calibrator. This error decreased significantly to -0.1 +/- 7.3% when corrections were applied for nonuniform attenuation and scatter. The animal experiment revealed an average error of -18.4 +/- 11.9% between the activity concentrations measured on the uncorrected pinhole SPECT images and measured with the gamma counter. This error decreased to -7.9 +/- 10.4% when attenuation and scatter correction was applied. Attenuation correction obtained from micro-CT data in combination with scatter correction allows accurate quantification in pinhole SPECT.".
- aggregation authorList BK958425.
- aggregation endPage "1063".
- aggregation issue "7".
- aggregation startPage "1049".
- aggregation volume "36".
- aggregation aggregates 3128111.
- aggregation isDescribedBy 2915878.
- aggregation similarTo s00259-009-1062-8.
- aggregation similarTo LU-2915878.