Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2916006#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B328289.
- aggregation creator B328290.
- aggregation creator B328291.
- aggregation creator B328292.
- aggregation creator B328293.
- aggregation creator B328294.
- aggregation creator B328295.
- aggregation creator B328296.
- aggregation creator B328297.
- aggregation creator person.
- aggregation date "2007".
- aggregation format "application/pdf".
- aggregation hasFormat 2916006.bibtex.
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- aggregation isPartOf urn:issn:0161-5505.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Technology and Engineering".
- aggregation title "Intramyocardial implantation of bone marrow-derived stem cells enhances perfusion in chronic myocardial infarction: dependency on initial perfusion depth and follow-up assessed by gated pinhole SPECT".
- aggregation abstract "Cell therapy-induced changes in the perfusion of areas of myocardial infarction (MI) remain unclear. This study investigated whether an original pinhole SPECT technique could be applied to a rat Ml model to analyze local improvement in myocardial perfusion relating to engraftment sites of bone marrow-derived stem cells (BMSCs). Methods: Four-month-old MI rats were either untreated (n = 8) or treated (n = 10) by intramyocardial injection of (111)in-labeled BMSCs. Early distribution of In-111-BMSCs within the MI target was evidenced by dual In-111/Tc-99m pinhole SPECT 48 h later. Myocardial perfusion was serially monitored by Tc-99m-sestamibi pinhole gated SPECT up to 3 mo after transplantation. Results: Forty-eight hours after transplantation, In-111-BMSCs were observed in all treated rats and in 18 of their 32 underperfused MI segments (< 70% sestamibi uptake before transplantation). During the subsequent 3-mo follow-up, the perfusion of MI segments worsened in untreated rats (absolute change in sestamibi uptake, -3% +/- 3%; P < 0.05) but improved in treated rats (+4% +/- 7%; P < 0.05). This perfusion improvement was unrelated to the initial detection of In-111-BMSCs (+2% +/- 6% in segments with In-111-BMSCs vs. +5% +/- 7% in those without; not statistically significant) but was strongly associated with less severe perfusion defects before transplantation (+6% +/- 6% in segments with 60%-70% sestamibi uptake [n = 19] vs. 1% +/- 6% in those with < 60% uptake [n = 13]; P = 0.003). Conclusion: When BMSCs are injected within chronic Ml, perfusion enhancement predominates in the MI areas showing a high enough residual perfusion before treatment but not in those of the initial cell engraftment, giving evidence of dependency on the perfusion and metabolic environment at implantation sites.".
- aggregation authorList BK619350.
- aggregation endPage "412".
- aggregation issue "3".
- aggregation startPage "405".
- aggregation volume "48".
- aggregation aggregates 3132755.
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