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- aggregation classification "A1".
- aggregation creator B281632.
- aggregation creator B281633.
- aggregation creator B281634.
- aggregation creator B281635.
- aggregation creator B281636.
- aggregation creator B281637.
- aggregation creator B281638.
- aggregation creator B281639.
- aggregation creator B281640.
- aggregation creator person.
- aggregation date "2006".
- aggregation format "application/pdf".
- aggregation hasFormat 2916041.bibtex.
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- aggregation isPartOf urn:issn:1619-7070.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Technology and Engineering".
- aggregation title "Feasibility of in vivo dual-energy myocardial SPECT for monitoring the distribution of transplanted cells in relation to the infarction site".
- aggregation abstract "Purpose: Cell therapy using bone marrow mesenchymal stem cells (BMSCs) shows promise in the treatment of myocardial infarction (MI) but accurate cell delivery within MI areas remains critical. In the present study, we tested the feasibility of in vivo pinhole SPECT imaging for monitoring the sites of intramyocardial implanted BMSCs in relation to targeted MI areas in rats. Methods: BMSCs were labelled with In-111-oxine and injected within the fibrotic areas of 3-month-old MI in ten rats. Two days later, dual In-111/Tc-99m-sestamibi pinhole SPECT was recorded for localisation of In-111-BMSCs on a 15-segment left ventricular (LV) division. Additional Tc-99m-sestamibi pinhole SPECT had been performed 1 month earlier and on the day before transplantation. In vitro counting on histological sections was used to validate the pinhole SPECT determination of In-111-BMSC activity within LV segments. Results: The underperfused MI area ( segments with < 70% uptake) was stable between the Tc-99m-sestamibi SPECT study recorded at 1 month (4.6 +/- 1.9 segments) and at 1 day (4.7 +/- 2.3 segments) before transplantation. In-111-BMSCs were detected by dual-energy SPECT in 56 segments: 33 (59%) were underperfused MI segments but 23 (41%) were not ( 14 adjacent and nine remote segments). Finally, In-111-labelled BMSCs were not detected in 14 out of the 47 (30%) underperfused MI segments. Conclusion: When BMSCs are injected within MI areas in rats, sites of early cell retention do not always match the targeted MI areas. The dual-energy pinhole SPECT technique may be used for monitoring the sites of early retention of implanted BMSCs and the data obtained may have critical importance when analysing the effects of cardiac cell therapy.".
- aggregation authorList BK559563.
- aggregation endPage "715".
- aggregation issue "6".
- aggregation startPage "709".
- aggregation volume "33".
- aggregation aggregates 3128179.
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- aggregation similarTo s00259-006-0075-9.
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