Matches in UGent Biblio for { <https://biblio.ugent.be/publication/294857#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B127479.
- aggregation creator B127480.
- aggregation creator B127481.
- aggregation creator B127482.
- aggregation creator person.
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- aggregation date "2004".
- aggregation format "application/pdf".
- aggregation hasFormat 294857.bibtex.
- aggregation hasFormat 294857.csv.
- aggregation hasFormat 294857.dc.
- aggregation hasFormat 294857.didl.
- aggregation hasFormat 294857.doc.
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- aggregation isPartOf urn:issn:1066-5099.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids".
- aggregation abstract "Embryonic stem (ES) cells, which can differentiate into almost all types of cells, have been derived from the house mouse Mus musculus, rat, rabbit, humans, and other species. Transmission of the genotype to the offspring of chimeras has been achieved only with M. musculus ES cells. limiting targeted mutagenesis using ES cells to this species. Mus spretus, which exhibits many genetic polymorphisms with M. musculus, displays dominant resistance to cancer and inflammation, making derived inbred strains very useful in positional cloning and interspecies mapping. We show here for the first time the derivation of ES cells from hybrid blastocysts, obtained by the mating of two different species, namely Mus muscalus and Mus spretus, and their use for the generation of chimeric mice that transmit the Mus spretus genotype and phenotype to the offspring. These hybrid ES cells allow the genetic manipulation of Mus spretus, as an alternative to Mus musculus.".
- aggregation authorList BK327763.
- aggregation endPage "447".
- aggregation issue "4".
- aggregation startPage "441".
- aggregation volume "22".
- aggregation aggregates 2934321.
- aggregation isDescribedBy 294857.
- aggregation similarTo stemcells.22-4-441.
- aggregation similarTo LU-294857.