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- aggregation classification "A1".
- aggregation creator B140654.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2004".
- aggregation format "application/pdf".
- aggregation hasFormat 295101.bibtex.
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- aggregation isPartOf urn:issn:0022-0302.
- aggregation language "eng".
- aggregation publisher "AMER DAIRY SCIENCE ASSOC".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Differential effects of steroids and retinoids on bovine myelopoiesis in vitro".
- aggregation abstract "Pregnancy and parturition are associated with physiological changes caused by steroid hormones. Alterations in number, maturity, and function of polymorphonuclear leukocytes observed in dairy cows at parturition suggest a common causative relationship with steroid hormones. This study was designed to investigate the effects of progesterone, 17-beta-estradiol, and hydrocortisone on the proliferation of bovine progenitor cells. An in vitro culturing system was used, and colonies were scored after 7 d of incubation. At low concentrations, 17-beta-estradiol inhibited proliferation of granulocyte progenitor cells. Hydrocortisone reduced growth of granulocyte and monocyte colonies, whereas myelopoiesis was not altered by progesterone. Furthermore, we studied the effect of retinoids on colony formation of bovine bone marrow cells. All-trans- and 9-cis-retinoic acid stimulated growth of granulocyte colonies and inhibited proliferation of the monocyte lineage. The addition of the 13-cis-isomer also increased numbers of granulocyte colony-forming units. This study indicates that steroid hormones may be responsible for alterations in the bovine hematopoietic profiles observed in circulation during the postpartum period. White blood cells, especially polymorphonuclear leukocytes, which are derived from bone marrow, are an important first line defense against mastitis. Therefore, these effects of steroids might contribute to the increased susceptibility of dairy cows to Escherichia coli mastitis. We furthermore hypothesize that an important role might be attributed to retinoic acid in its regulation of bovine myelopoiesis. Modulation of myelopoiesis in favor of the granulocyte lineage during the acute-phase reaction may be an adaptive mechanism designed to increase the capacity of first-line defense to intramammary infections.".
- aggregation authorList BK358114.
- aggregation endPage "1195".
- aggregation issue "5".
- aggregation startPage "1188".
- aggregation volume "87".
- aggregation aggregates 984688.
- aggregation isDescribedBy 295101.
- aggregation similarTo LU-295101.