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- aggregation classification "A1".
- aggregation creator B373512.
- aggregation creator B373513.
- aggregation creator B373514.
- aggregation creator B373515.
- aggregation creator B373516.
- aggregation creator B373517.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 2959380.bibtex.
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- aggregation isPartOf urn:issn:0105-4538.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "The association between bacterial colonization and inflammatory pattern in Chinese chronic rhinosinusitis patients with nasal polyps".
- aggregation abstract "Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) can be subdivided according to the mucosal inflammatory patterns. In mainland China, apart from interleukin (IL)-5-positive and IL-17-positive polyps, a large group of patients with IL-5/IL-17/interferon-gamma (IFN gamma)-negative nasal polyps (referred to as key cytokine-negative (KCN) polyps) can be found. Objective: To further study the KCN polyps and evaluate the associations between bacterial colonization and mucosal inflammatory pattern in KCN vs IL-5-positive nasal polyps. Methods: Nasal polyp or nasal turbinate tissue was obtained from 89 Chinese CRSwNP patients and 36 nonatopic control subjects during surgery. Samples without and after SEB exposure were processed for the assessment of pro-inflammatory cytokines and mediators by immunoassay. Prior to surgery, nasal swabs were taken from each patient for microbiological evaluation. Results: Overall, 80% polyp tissue did not express IL-5, with about 70% (49/71) of these being KCN. Key cytokine-negative nasal polyps were characterized by the synthesis of mediators promoting neutrophilic inflammation (myeloperoxidase (MPO), IL-1 beta, IL-6 and IL-8), whereas IL-5-positive nasal polyps were characterized by the synthesis of mediators promoting eosinophilic inflammation (IL-5, ECP, total IgE and SE-IgE). Key cytokine-negative nasal polyps were associated with greater Gram-negative bacterial load compared with controls, while IL-5-positive nasal polyps were associated with greater Gram-positive bacterial colonization vs controls and KCN polyps. Conclusion: Our findings suggest that the bacteria colonizing nasal polyps of CRSwNP patients may impact on or be determined by the presence/absence of IL-5.".
- aggregation authorList BK675423.
- aggregation endPage "1303".
- aggregation issue "10".
- aggregation startPage "1296".
- aggregation volume "66".
- aggregation aggregates 2961687.
- aggregation isDescribedBy 2959380.
- aggregation similarTo j.1398-9995.2011.02637.x.
- aggregation similarTo LU-2959380.