Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2965070#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B434994.
- aggregation creator B434995.
- aggregation creator B434996.
- aggregation creator B434997.
- aggregation creator B434998.
- aggregation creator B434999.
- aggregation creator B435000.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2965070.bibtex.
- aggregation hasFormat 2965070.csv.
- aggregation hasFormat 2965070.dc.
- aggregation hasFormat 2965070.didl.
- aggregation hasFormat 2965070.doc.
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- aggregation hasFormat 2965070.txt.
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- aggregation hasFormat 2965070.yaml.
- aggregation isPartOf urn:issn:1534-5807.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Genetic framework of cyclin-dependent kinase function in Arabidopsis".
- aggregation abstract "Cyclin-dependent kinases (CDKs) are at the heart of eukaryotic cell-cycle control. The yeast Cdc2/CDC28 PSTAIRE kinase and its orthologs such as the mammalian Cdk1 have been found to be indispensable for cell-cycle progression in all eukaryotes investigated so far. CDKA;1 is the only PSTAIRE kinase in the flowering plant Arabidopsis and can rescue Cdc2/CDC28 mutants. Here, we show that cdka;1 null mutants are viable but display specific cell-cycle and developmental defects, e.g., in S phase entry and stem cell maintenance. We unravel that the crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and that codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants. Our work further revealed a basic cell-cycle control system relying on two plant-specific B1-type CDKs, and the triple cdk mutants displayed an early germline arrest. Taken together, our data indicate divergent functional differentiation of Cdc2-type kinases during eukaryote evolution.".
- aggregation authorList BK757951.
- aggregation endPage "1040".
- aggregation issue "5".
- aggregation startPage "1030".
- aggregation volume "22".
- aggregation aggregates 2965081.
- aggregation isDescribedBy 2965070.
- aggregation similarTo j.devcel.2012.02.015.
- aggregation similarTo LU-2965070.