Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2971878#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B618102.
- aggregation creator B618103.
- aggregation creator B618104.
- aggregation creator B618105.
- aggregation creator B618106.
- aggregation creator B618107.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 2971878.bibtex.
- aggregation hasFormat 2971878.csv.
- aggregation hasFormat 2971878.dc.
- aggregation hasFormat 2971878.didl.
- aggregation hasFormat 2971878.doc.
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- aggregation hasFormat 2971878.txt.
- aggregation hasFormat 2971878.xls.
- aggregation hasFormat 2971878.yaml.
- aggregation isPartOf urn:issn:1574-0153.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma".
- aggregation abstract "Successful therapy of the non-small cell lung carcinoma (NSCLC) depends on its early detection, and non-invasive detection methods are preferred. As plasma proteins are modified by N-linked glycosylation, we tested the importance of the N-glycan profile in diagnosing and prognosticating NSCLC. We analysed desialylated plasma samples from 75 NSCLC patients, and 71 healthy individuals by the high-throughput DNA sequencer-based carbohydrate analytical profiling technique. We detected alterations in the levels of several N-glycans in NSCLC patients. Total alpha-1,6-core fucosylated biantennaries (NGA2F, NG1A2F, NA2F) and total bisecting alpha-1,6-core fucosylated biantennaries (NGA2FB, NA2FB) were reduced in NSCLC patients, whereas the branching alpha-1,3-fucosylated triantennary N-glycan (NA3FB) was increased. Best diagnostic accuracy was identified for NG1A2F. NSCLC patients with TNM stage I stage did not show further differences, but patients with higher stages did (TNM II to IV). Those patients additionally had a reduced level in the alpha-1,6-core fucosylated structure NA2F with parallel increase in the non-fucosylated structure NA2. In this regard, NSCLC patients with a relatively low amount of NA2 per NA2F had a better three-year survival than patients with high amount. NSCLC patients show an altered N-glycan profile of plasma proteins that may be regarded as a supportive tool for cancer diagnosis.".
- aggregation authorList BK978162.
- aggregation endPage "154".
- aggregation issue "3-4".
- aggregation startPage "145".
- aggregation volume "10".
- aggregation aggregates 2971895.
- aggregation isDescribedBy 2971878.
- aggregation similarTo CBM-2012-0239.
- aggregation similarTo LU-2971878.