Matches in UGent Biblio for { <https://biblio.ugent.be/publication/2974299#aggregation> ?p ?o. }
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- aggregation classification "A1".
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- aggregation date "2012".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:0179-7158.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Intensity-modulated arc therapy with cisplatin as neo-adjuvant treatment for primary irresectable cervical cancer: toxicity, tumour response and outcome".
- aggregation abstract "The goal of this work was to evaluate the feasibility and outcome of intensity-modulated arc therapy +/- A cisplatin (IMAT +/- A C) followed by hysterectomy for locally advanced cervical cancer. A total of 30 patients were included in the study. The primary tumour and PET-positive lymph node(s) received a simultaneous integrated boost. Four weeks after IMAT +/- A C treatment, response was evaluated. Resection consisted of hysterectomy with or without lymphadenectomy. Tumour response, acute and late radiation toxicity, postoperative morbidity and outcome were evaluated. All hysterectomy specimens were macroscopically tumour-free with negative resection margins; pathological complete response was 40%. In 2 patients, one resected lymph node was positive. There was no excess in postoperative morbidity. Apart from two grade 3 hematologic toxicities, no grade 3 or 4 acute radiation toxicity was observed. No grade 3, 1 grade 4 (4%) intestinal, and 4 grade 3 (14%) urinary late toxicities were observed. The 2-year local and regional control rates were 96% and 100%, respectively. The 2-year distant control rate was 92%. Actuarial 2-year progression free survival rate was 89%. Actuarial 1- and 2-year overall survival rates were 96% and 91%, while 3-year overall survival was 84%. Surgery after IMAT +/- A C is feasible with low postoperative morbidity and radiation toxicity. Local, regional, distant control and survival rates are promising.".
- aggregation authorList BK679053.
- aggregation endPage "581".
- aggregation issue "7".
- aggregation startPage "576".
- aggregation volume "188".
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