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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2004".
- aggregation format "application/pdf".
- aggregation hasFormat 298757.bibtex.
- aggregation hasFormat 298757.csv.
- aggregation hasFormat 298757.dc.
- aggregation hasFormat 298757.didl.
- aggregation hasFormat 298757.doc.
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- aggregation hasFormat 298757.mods.
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- aggregation hasFormat 298757.yaml.
- aggregation isPartOf urn:issn:1367-4803.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences".
- aggregation abstract "Motivation: Most non-coding RNAs are characterized by a specific secondary and tertiary structure that determines their function. Here, we investigate the folding energy of the secondary structure of non-coding RNA sequences, such as microRNA precursors, transfer RNAs and ribosomal RNAs in several eukaryotic taxa. Statistical biases are assessed by a randomization test, in which the predicted minimum free energy of folding is compared with values obtained for structures inferred from randomly shuffling the original sequences. Results: In contrast with transfer RNAs and ribosomal RNAs, the majority of the microRNA sequences clearly exhibit a folding free energy that is considerably lower than that for shuffled sequences, indicating a high tendency in the sequence towards a stable secondary structure. A possible usage of this statistical test in the framework of the detection of genuine miRNA sequences is discussed.".
- aggregation authorList BK325939.
- aggregation endPage "2917".
- aggregation issue "17".
- aggregation startPage "2911".
- aggregation volume "20".
- aggregation aggregates 3082959.
- aggregation isDescribedBy 298757.
- aggregation similarTo bth374.
- aggregation similarTo LU-298757.