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- aggregation date "2012".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:1467-2987.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Comparison of analgesic efficacy of epidural methadone or ropivacaine/methadone with or without pre-operative oral tepoxalin in dogs undergoing tuberositas tibiae advancement surgery".
- aggregation abstract "Objective : To investigate the clinical efficacy of four analgesia protocols in dogs undergoing tibial tuberosity advancement (TTA). Study design : Prospective, randomized, blinded study. Animals : Thirty-two client owned dogs undergoing TTA-surgery. Methods : Dogs (n = 8 per treatment) received an oral placebo (PM and PRM) or tepoxalin (10 mg kg)1) tablet (TM and TRM) once daily for 1 week before surgery. Epidural methadone (0.1 mg kg)1) (PM and TM) or the epidural combination methadone (0.1 mg kg)1)/ropivacaine 0.75% (1.65 mg kg)1) (PRM and TRM) was administered after induction of anaesthesia. Intra-operative fentanyl requirements (2 lg kg)1 IV) and end-tidal isoflurane concentration after 60 minutes of anaesthesia (FE¢ISO60) were recorded. Post-operative analgesia was evaluated hourly from 1 to 8 and at 20 hours post-extubation with a visual analogue scale (VAS) and the University of Melbourne Pain Scale (UMPS). If VAS > 50 and/or UMPS > 10, rescue methadone (0.1 mg kg)1) was administered IV. Analgesic duration (time from epidural until post-operative rescue analgesia) and time to standing were recorded. Normally distributed variables were analysed with an F-test (a = 0.05) or t-test for pairwise inter-treatment comparisons (Bonferonni adjusted a = 0.0083). Non-normally distributed data were analysed with the Kruskall–Wallis test (a = 0.05orBonferonni adjusteda = 0.005for intertreatment comparison of post-operative pain scores). Results : More intra-operative analgesia interventions were required in PM [2 (0–11)] [median (range)] and TM [2 (1–2)] compared to PRM (0) and TRM (0). FE¢ISO60 was significantly lower in (PRM + TRM) compared to (PM + TM). Analgesic duration was shorter in PM (459 ± 276 minutes) (mean ± SD) and TM (318 ± 152 minutes) compared to TRM (853 ± 288 minutes), but not to PRM (554 ± 234 minutes). Times to standing were longer in the ropivacaine treatments compared to TM. Conclusions and clinical relevance : Inclusion of epidural ropivacaine resulted in reduction of FEISO60, avoidance of intra-operative fentanyl administration, a longer duration of post-operative analgesia (in TRM) and a delay in time to standing compared to TM.".
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- aggregation volume "39".
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