Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3059318#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B376313.
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- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3059318.bibtex.
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- aggregation isPartOf urn:issn:1534-5807.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation".
- aggregation abstract "Most adult mammalian tissues are quiescent, with rare cell divisions serving to maintain homeostasis. At present, the isolation and study of replicating cells from their in vivo niche typically involves immunostaining for intracellular markers of proliferation, causing the loss of sensitive biological material. We describe a transgenic mouse strain, expressing a CyclinB1-GFP fusion reporter, that marks replicating cells in the S/G2/M phases of the cell cycle. Using flow cytometry, we isolate live replicating cells from the liver and compare their transcriptome to that of quiescent cells to reveal gene expression programs associated with cell proliferation in vivo. We find that replicating hepatocytes have reduced expression of genes characteristic of liver differentiation. This reporter system provides a powerful platform for gene expression and metabolic and functional studies of replicating cells in their in vivo niche.".
- aggregation authorList BK679582.
- aggregation endPage "690".
- aggregation issue "4".
- aggregation startPage "681".
- aggregation volume "23".
- aggregation aggregates 3207446.
- aggregation isDescribedBy 3059318.
- aggregation similarTo j.devcel.2012.08.009.
- aggregation similarTo LU-3059318.