Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3064471#aggregation> ?p ?o. }
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- aggregation classification "C3".
- aggregation creator person.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3064471.bibtex.
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- aggregation language "eng".
- aggregation publisher "Koninklijke Vlaamse Academie van België voor Wetenschappen en Kunsten".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Contrasting replication kinetics of feline enteric coronavirus and feline infectious peritonitis virus in newly established feline intestinal epithelial cell cultures".
- aggregation abstract "Feline infectious peritonitis (FIP) is the most feared infectious cause of death in cats, induced by feline infectious peritonitis virus (FIPV). This coronavirus is a virulent mutant of the harmless, ubiquitous feline enteric coronavirus (FECV). Up till now, feline coronavirus (FCoV) research has been hampered by the lack of reliable in vitro models to perform comparative studies with FECV and FIPV and to cultivate and titrate field strains. Hence, it is still unclear why FECV and FIPV behave clinically and epidemiologically so different. In this study, infection and growth properties of FECV 79-1683 and FIPV 79-1146 were compared in primary cultures of ileocytes and colonocytes. FECV replicated efficiently in these cells, whereas FIPV did not. In addition, long-term cultures were derived from primary ileocytes and colonocytes by SV40-Tag- and human Telomerase Reverse Transcriptase (hTERT)-induced immortalization. Since comparable infection and growth characteristics were seen as in primary cultures, these cell lines can be considered as reliable models for elucidating the enteric pathogenesis of FCoVs. Interestingly, the continuous cultures were also sensitive to infection with field enteric strains, for which in vitro cultivation has never been achieved. In conclusion, a new reliable model for FCoV investigation and growth of enteric field strains was established. It was shown that only FECV fully replicates in intestinal epithelial cells, giving an explanation for the observation that FECV is the main pathotype circulation among cats.".
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