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- aggregation classification "A1".
- aggregation creator B440568.
- aggregation creator B440569.
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- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3064856.bibtex.
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- aggregation isPartOf urn:issn:0021-9525.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration".
- aggregation abstract "During keratinocyte differentiation and stratification, cells undergo extensive remodeling of their actin cytoskeleton, which is important to control cell mobility and to coordinate and stabilize adhesive structures necessary for functional epithelia. Limited knowledge exists on how the actin cytoskeleton is remodeled in epithelial stratification and whether cell shape is a key determinant to trigger terminal differentiation. In this paper, using human keratinocytes and mouse epidermis as models, we implicate miR-24 in actin adhesion dynamics and demonstrate that miR-24 directly controls actin cable formation and cell mobility. miR-24 overexpression in proliferating cells was sufficient to trigger keratinocyte differentiation both in vitro and in vivo and directly repressed cytoskeletal modulators (PAK4, Tks5, and ArhGAP19). Silencing of these targets recapitulated the effects of miR-24 overexpression. Our results uncover a new regulatory pathway involving a differentiation-promoting micro-ribonucleic acid that regulates actin adhesion dynamics in human and mouse epidermis.".
- aggregation authorList BK768941.
- aggregation endPage "363".
- aggregation issue "2".
- aggregation startPage "347".
- aggregation volume "199".
- aggregation aggregates 3064903.
- aggregation isDescribedBy 3064856.
- aggregation similarTo jcb.201203134.
- aggregation similarTo LU-3064856.