Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3092677#aggregation> ?p ?o. }
Showing items 1 to 43 of
43
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B441497.
- aggregation creator B441498.
- aggregation creator B441499.
- aggregation creator B441500.
- aggregation creator B441501.
- aggregation creator B441502.
- aggregation creator B441503.
- aggregation creator B441504.
- aggregation creator B441505.
- aggregation creator B441506.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3092677.bibtex.
- aggregation hasFormat 3092677.csv.
- aggregation hasFormat 3092677.dc.
- aggregation hasFormat 3092677.didl.
- aggregation hasFormat 3092677.doc.
- aggregation hasFormat 3092677.json.
- aggregation hasFormat 3092677.mets.
- aggregation hasFormat 3092677.mods.
- aggregation hasFormat 3092677.rdf.
- aggregation hasFormat 3092677.ris.
- aggregation hasFormat 3092677.txt.
- aggregation hasFormat 3092677.xls.
- aggregation hasFormat 3092677.yaml.
- aggregation isPartOf urn:issn:0012-1797.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance".
- aggregation abstract "The stress protein heat shock protein 60 (Hsp60) induces secretion of proinflammatory mediators from murine adipocytes. This study aimed to study Hsp60 as a mediator of adipose tissue inflammation and skeletal muscle cell (SkMC) insulin sensitivity and to quantify plasma Hsp60 concentrations in lean and obese individuals. Regulation of Hsp60 release and Hsp60-induced cytokine secretion and signaling was measured in human adipocytes and SkMCs. Adipocytes exhibited higher Hsp60 release than preadipocytes and SkMCs, which was further stimulated by cytokines and Toll-like receptor (TLR)-4 activation. Hsp60 activated extracellular signal-related lcinase (ERK)-1/2, Jun NH2-terminal kinase (JNK), p38, nuclear factor (NF)-kappa B, and impaired insulin-stimulated Akt phosphorylation in adipocytes. Furthermore, Hsp60 stimulated adipocytes to secrete tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. In SkMCs, Hsp60 activated ERK1/2, JNK, and NF-kappa B and inhibits insulin signaling and insulin-stimulated glucose uptake. SkMCs released IL-6, IL-8, and monocyte chemoattractant protein-1 on Hsp60 stimulation. Plasma Hsp60 was higher in obese males than in lean males and correlated positively with BMI, blood pressure, leptin, and homeostasis model assessment-insulin resistance. In summary, Hsp60 is released by human adipocytes, increased in plasma of obese humans, and induces insulin resistance. This is accompanied by activation of proinflammatory signaling in human adipocytes and SkMCs. Thus, Hsp60 might be a factor underlying adipose tissue inflammation and obesity-associated metabolic disorders.".
- aggregation authorList BK770434.
- aggregation endPage "625".
- aggregation issue "3".
- aggregation startPage "615".
- aggregation volume "61".
- aggregation aggregates 3094449.
- aggregation isDescribedBy 3092677.
- aggregation similarTo db10-1574.
- aggregation similarTo LU-3092677.