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- aggregation classification "C3".
- aggregation creator B75781.
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- aggregation date "2012".
- aggregation hasFormat 3099834.bibtex.
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- aggregation language "eng".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Bioinformatics tools for the design of antisense RNA and aptamers".
- aggregation abstract "Next to its function as information carrier (mRNA), RNA plays an important role in different regulatory mechanisms that steer the expression of genes and as such control the cell's behaviour, e.g., by interacting with mRNA (antisense RNA) or with small molecules such as glucosamine-6-phosphate (aptamer riboswitches). These functions and properties render RNA molecules interesting targets to use as genetic engineering tools for the optimization microbial production hosts. Nowadays, these tools are mainly created on a trial and error basis because information on the interactions of RNA molecules is scarcely available. Hence, a bioinformatics analysis of RNA-RNA and RNA-ligand interactions may lead to new insights and a faster development of these RNA structures. Through the years different software packages have been developed for the prediction of the secondary and tertiary structure of RNA which will be used in this study. Ultimately, this computational approach can be applied for directing the design of tailor made RNA molecules, which have numerous applications in metabolic engineering and synthetic biology.".
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- aggregation isDescribedBy 3099834.
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