Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3151396#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B504376.
- aggregation creator B504377.
- aggregation creator B504378.
- aggregation creator B504379.
- aggregation creator B504380.
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- aggregation creator B504385.
- aggregation creator person.
- aggregation date "2012".
- aggregation hasFormat 3151396.bibtex.
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- aggregation isPartOf urn:issn:1387-2877.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression".
- aggregation abstract "Indoleamine 2,3-dioxygenase (IDO), an enzyme which is activated by pro-inflammatory cytokines, has been suggested as a potential link between neuroinflammatory processes in neurodegenerative diseases (like Alzheimer's disease) and depression. The present study aimed to determine whether neuroinflammation-induced increased IDO levels in the mammalian brain will lead to depressive-like behavior. Neuroinflammation was initiated in mice by a single intracerebroventricular injection of lipopolysaccharide (LPS). Cerebral inflammation was monitored 1, 2, 3 and 4 days after the injection with small-animal positron emission tomography (PET) using the inflammatory marker [C-11]-PK11195. In the presence or absence of systemically applied 1-methyl-tryptophan (1-MT), a competitive IDO-inhibitor, we assessed the development of depressive-like behavioral symptoms in parallel with IDO expression and activity. The PK11195 PET signal reached a highly significant peak 3 days after LPS injection, while these animals displayed a significant increase of depressive-like behavior in the forced swim test compared to vehicle-injected animals. These findings were paralleled by a significant increase of IDO in the brainstem, and an increased kynurenine/tryptophan ratio in the serum. Moreover, we report here for the first time, that inhibition of IDO by 1-MT in centrally induced neuroinflammation under experimental conditions can prevent the development of depressive-like behavior.".
- aggregation authorList BK845421.
- aggregation endPage "915".
- aggregation issue "4".
- aggregation startPage "905".
- aggregation volume "28".
- aggregation isDescribedBy 3151396.
- aggregation similarTo JAD-2011-111097.
- aggregation similarTo LU-3151396.